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Transcriptomic analysis of Parkinson’s disease and multiple system atrophy patient iPSC-derived oligodendrocytes reveal changes in maturation and immune reactive properties induced by alpha-synuclein

C. Azevedo, G. Teku, Y. Pomeshchik, J.F. Reyes, M. Chumarina, K. Russ, E. Savchenko, A. Hammarberg, N.J. Lamas, A. Collin, G.K. Gouras, O. Klementieva, M. Hallbeck, R Taipa, M. Vihinen, L. Roybon

 In Press in PNAS

TNFα and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

K. Russ; G. Teku; L. Bousset; V. Redeker; S. Piel; E. Savchenko; Y. Pomeshchik; J. Savistchenko; T.C. Stummann; C. Azevedo; A. Collin; S. Goldwurm; K. Fog; E. Elmer; M. Vihinen; R. Melki; L. Roybon

Cell Reports

Transcriptomic and proteomic data

Transcriptomic data can be also found at:


Human iPSC-derived hippocampal spheroids: an innovative tool for stratifying Alzheimer's disease patient specific cellular phenotypes and developing therapies

Y. Pomeshchik, O. Klementieva, J. Gil, I. Martinsson, M. Grønning Hansen, T. de Vries, A. Sancho-Balsells, K. Russ, E. Savchenko, A Collin, A.R. Vaz, S. Bagnoli, B. Nacmias, C. Rampon, S. Sorbi, D. Brites, G. Marko-Varga, Z. Kokaia, M. Rezeli, G.K. Gouras, L. Roybon

Stem Cell Reports

Proteomic data:

Transcriptomic data:

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

M. Chumarina, K. Russ, C. Azevedo, A. Heuer, M. Pihl, A. Collin, E. Åsander Frostner, E. Elmer, P. Hyttel, G. Cappelletti, M. Zini, S. Goldwurm, L. Roybon

Acta Neuropathologica Communications

Proteomic data:

FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes

E. Savchenko, G. N. Teku, A. Boza-Serrano, K. Russ, M. Berns, T. Deierborg, N. J. Lamas, H. Wichterle, J. Rothstein, C. E. Henderson, M. Vihinen, L. Roybon 

Scientific Reports

Transcriptomic data:



KEGG enrichment diagram

KEGG pathways

volcano plot