The CSC laboratory - Presentation
Welcome to the CSC lab!
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- New study by Pomeshchik et al published in Stem Cell Reports. In this study, Pomeshchik and colleagues report on the generation of iPSC-derived hippocampal neurons and how they can be used to model Alzheimer's disease and develop new therapeutic solutions. Click here to access the study and the press release (in Swedish and in English).
- This year, the team building event took place in Ven island!
- Congratulation Carla! PhD student Ms. Carla Azevedo brilliantly defended her thesis on April 30th 2020. The thesis defense took place virtually via Zoom. She is now Dr. CAzevedo and has a brilliant career ahead of her.
- New study published in Human Molecular Genetics by Brazdis and colleagues shows brain region-specific neuronal vulnerability in a human iPSC-based model of familial Parkinson's disease.
Research in the laboratory attempts to define pathogenic cellular and molecular mechanisms involved in synucleiopathies, in particular Parkinson's disease and multiple system atrophy, and Alzheimer's disease. To this aim, we generate induced pluripotent stem cells (iPSC) from patients, which we utilize to understand cell autonomous and non-cell autonomous processes that lead to neuronal damage.
By generating iPSCs from patients suffering familial and idiopathic forms of the diseases, we aim to elucidate causative mechanisms leading to neural cell dysfunction, and neurodegeneration.
Our cutting-edge approach will allow for the identification of new molecular targets, which could be used for the development of new diagnostic tools for early diagnosis, as well as for the stratification and recruitment of patients for future clinical trials.